I have loaded the 220gr. Speer in the .35 Rem., but have never shot an animal with that bullet, in that caliber. I have shot a lot of paper targets with it at 2000 fps + or _ , and they are accurate enough. However, I reserve most of the heavier .35 caliber bullets for the .35 Whelen, where their extra weight and velocity seems to be better suited in relation to the powder capacity. I suppose if the .35 Rem. were my only "Elk" gun, I would use the 220gr. and drive it as fast as "designed pressure" would allow for the rifle and plan on getting close as possible to the game to ensure bullet "expansion" was commensurate with penetration. Given those parameters, I would expect it to do the job. (For what its worth, my two favorite bullets in the .35 Rem. is the 180gr. Speer and the 200gr. Rem. Core-LoKT.) My .02