Given a decent meplat, the RFN do fine. Given a decent alloy, and adequate velocity, they expand well, too, if bone is hit.
I've taken a number of deer with the .452" Lee 255gr RFN. It has a generous meplat and performs indistinguishable from the 270gr RCBS SWC at similar velocities. However, the SWC won't function through my WinMod-94, whereas the RFN feeds very smoothly.
My load is only 7.8-8.2gr of Universal so only runs ~1,200fps from the rifle and ~900fps from handguns, but is enough to put them through deer at up to 75yds. (longest shot I've made with such load/caliber on deer- gun has iron (reciever) sights only.).
The original .45cal loads with the very small meplat are the RFN's that have a poor reputation for game/defense performance. But, they were also only running 600-700fps, also.