I took the leap this fall and loaded blackpowder .45-70's for hunting with my Shiloh Sharps.
I tried several different loads, with two different bullets, two types of powder, and varying charge weights and powder compression.
Here's what I ended up with:
First full length resized the cases. (mine were Starline)
Federal Magnum Rifle primers. (I've since tried the CCI Benchrest primers with good results as well)
67 grains of Goex 2F Express, trickled through a drop tube.
Then a .060 veggie fiber over powder wad.
Compressed the powder approx. 1/4".
Bullet is a 405 grain SPG lubed lead flatpoint roundnose, (commercial cast bullet by Montana Precision Swaging)
Nice consistent roll crimp.
Powder compression, bullet seating, and crimp done in seperate steps to avoid deforming the bullets.
This load pretty much shot into one hole at 25 yards, about an inch at 50 yards, and was still around an inc and a half at 100 yards.
Fouling was manageable, and I could shoot maybe 6 to 10 shots between wiping with no loss of accuracy.
I tried Goex Cartridge, and it felt a little stouter, but the fouling was drier and cakier, and accuracy deteriorated quickly.
Tried less powder, (and therefore less compression), and my rifle didn't like it.
I tried lighter bullets, but because they were shorter, they didn't carry enough lube, and fouling built up quickly and accuracy deteriorated.
Heavier bullets look promising, but I haven't experimented enough yet to know for sure.
I found that blackpowder works when you are doing everything consistently.
It's super important to pour the powder, work the press ram, etc., etc., exactly the same every time, just like it is in getting good accuracy from a muzzle loader.
Anyway, I had a lot of fun with it, and it felt great to come up with something that worked.
Good luck !
PS: I did take a deer with the load a couple weeks later... a spike buck who I would normally have let pass, but he had already been wounded thru the lower jaw and would not have survived the winter.