Unique ain't that bright. It's a dull orange at 45 ACP pressures of this type. And yeah, I've shot it under such conditions to know.
PJ, I was sort of getting after RR to use Unique to reduce the "blastier" tendency with the heavier loads in the first place. It's noticeably less than Power Pistol with the same velocities, and lower on flash as you well know. Save for those complaints, I like Power Pistol, but for defense load simulation or the real thing (whatever you're comfortable with) lower blast and flash for the same velocity is, to my way of thinking, a benefit.
Depending upon what type of powder measure is used, it should meter quite well enough. I do pretty well using the Lee discs and the Lyman 55, RCBS, etc. as the charge is large enough to avoid uneven flow given an adequately dimensioned hole in the measuring cavity. Not too small in diameter in relation to its length or vice versa, in other words.
If you're one of those who's comfortable with using handloads for defensive use, then I'd weigh the charges of Unique for the relatively small number of cartridges required to make the quality of the ammo as high as possible......we deserve no less. Such is no great burden in the 20 to fifty round "lots" of handloaded defensive ammo. Again, if you're comfortable with such a thing. If they're only for practice most measures should meter well enough to make weighing charges needless.
I do this with Herco, and have been loading some 230 JHP's that are the same bullet as found in Winchester's Personal Protection white box hollowpoints (which I rather like, and so do my pistols). I have this in bullet in bulk quantity for 10 bucks a hundred (good connections pay off sometimes). Since I find the factory ammo low on flash and blast I don't see any benefit to using a powder to reload its velocity equivalent that does.
Unique and Herco are my anal retentive handloader's idea of a perfect full power powder for standard velocity or higher performance loads for the 45 ACP. It has some drawbacks related to its grain size, but this is no great cross to bear when speaking of small quantities of handloaded ammunition or when using a compatible measure. Given its high bulk, and the fact that needed charges to get similar velocities or higher velocities are a little larger than such standards as Bullseye or W231, it gives maximum case filling qualities in a powder that is not particularly position sensitive anyway, a sort of double benefit.
When speaking of charge weight vs. bulk fill, Herco is just a little ahead of Unique, but has a little less flexibility on the low end. No matter......Red Dot is my choice for high volume shooting at low to standard velocities anyway as it gives good velocity at lower (and cheaper) charge weights. Unique and Herco could be standard velocity powders too, I guess, but optimized as I like I tend to employ them with jacketed hollowpoint ammo, or those loads that need somewhat more speed for whatever reason.
Ridge, the 1.220 to 1.230" overal length you and I specify is very good.....I have no qualms about using 6.5 Unique when the Hornady 230 HP is loaded to that length, and they do tend to penetrate well. Pressures should be on the upper end of the standard velocity range but quite manageable in any 45 ACP pistol. A bit more would be Plus P.