It might not be a bad idea with power and vibrations that a 45-70 can produce but I did no loctite mine and it has not come loose yet. I have been thinking about going back and putting loctite on the screws though. I should mention that mine is an SBL and it came with the XS leverrail installed and it didn't appear to have loctite on it from the factory because I did have to take one of the screws out to get the holes to line up to install the ghost sight which was not pre-installed.