We met a guy here that swears by, wait for it, Preparation H for his 22 lube. I have no idea if it works as all of my target ammo comes lubed from the factory. My preferred target practice ammo is subsonic, standard velocity stuff rated at ~1050 FPS or so and using a tried and true 40 grain projectile. I like CCI Standard Veloctiy (#0032 and #0035), Wolf Match Extra, Wolf Match Target. There are some great threads about this topic over at rimfire central, if you haven't already, I'd suggest stopping by there and reading up.
Another thing to look out for, and one that has worked very well for me, is not cleaning the rifle until it indicates it needs it. I used to clean my 22 bore after every shoot but, in my experience, it's better to just keep on shooting until your groups start to open up. Even then, I will typically only use a dry patch on some weed whacker line or on occasion a bore snake.
I'm no champion shooter, just sayin' what works for me based on the research I've done. Do stop on over to rimfire central and do some reading, there are some very knowledgeable folks over there and some great topics covering stuff like this including the topics of sorting by weight and rim thickness (both seem to be wasted time from my reading and experience) and on and on. And, heck, some rifles really can just shoot that bulk like nobodies business, as you know *every* rifle is an individual there...
Good luck.
--James