When I use to go every year and pull my boat we just stayed on I-75 all the way down to Naples and then cut across to Homestead and avoided the tolls that way. It is about the same drive but they are steady working on 75 around Tampa so you have to avoid hitting it a rush hour. We would leave after work and get to Islamorada around midnight. I can remember when the old bridges were there and the seven mile bridge was a narrow 2 lane road. The Keys were better back in those days but not the roads.The Keys are special, no doubt. Great fishing and then of course there's Duvall street and the infamous Sloppy Joes. Next time I go I'm gonna drive around all those ..mn toll roads.