Contrary to what it may sound like, with that kick killer, its easy to take the kick, and as long as you use the same bullet with different loads, the POA will be fairly similar. I like lead, so I seem to gravitate to the 400gr. variety. Using the 13gr of Unique or Trailboss for plinking and that 2400 load is good for hunting as long as you dont mind a little more arc than the 300's. Those 300's are fine, but the lead going slower makes for a more pleasant load in my estimation. Might even tone that load to 23 gr. or so of the 2400 to keep it more accurate with that long barrel. 25gr. of 2400 also works with a good Remington HP. That is not very fast, but definitely works, and is a powder puff compared to what you're shooting now.
Give it a try. You might become a convert. ;D The remington is the key component there, cause its so soft.
I know the trail boss/unique would work fine for hunting, but prefer that 2400. It really rocked the hogs world we used the other day. I can't believe I used to load those 400's at just under 2000fps for my mental security. It simply isn't needed. That CB will probably spit them out at 1500fps, and that really isn't all that slow. (much faster than Remington's express load)