I can shoot a penned buffalo anytime I have the money, several places out here have them. I "might" shoota yearling for meat/fun some day. Our "wild" buffalo are down in the Henry Mountains, draw hunt only. They are "wilder" than March Hares, and the area is very rugged. Not for me,ha!
I have shot all of my game here with 240W, 6mm/284; 6.5/284; 30.06; 300 winmag; 338 winmag; 220 Swift; 45 Colt ( Marlin of course); .375 H&H (for grins);25.06; .270; 280 Ackley Improved; 50 caliber muzzleloader with a Green Mountain 1/28" twist w/500gr conicals ( another hoot) and same rifle with a 240XTP in a TC sabot. I have used other calibers in other states and countries.
While I have always had a 45-70 of either a Browning or Marlin hanging around, I've never seemed to get a shot at anything with it, same with my last 444 and the Winchester 375Win. Lots of neat "walks in the woods", but no game,ha. I have only recently returned primarly to leverguns, about last 3 years. I have some 'catching up" to do. Between past surgeries and ministry demands, I've missed a few seasons. I could still say "I'm in my prime", but I may sound (and maybe look like) like Doc Holiday in Tombstone saying it,ha. I'm not in bad health, just bolted together and fighting the mid-drift "bulge", I'm still a contender! I focus more on antlerless for elk, but it's only due to the time of year I can get at them, both from scheduling/events and logictically.