I did use a lot of Unique before I found Trail Boss. I was always a little concerned about the small charges in a big case. I played around with fillers and wads. I checked and rechecked for double charges. I can't say I ever had a problem, but I kept a close eye on it. I'd still be using it if Trail Boss hadn't come around.
I like the way Trail Boss fills the case. And it smokes just a bit. I get some of the Black Powder appeal without the extra work.
You might give it a try when you get some time. Essentially you fill the case to the point that it touches the bullet, but doesn't compress the powder. You can reduce from there if you want to go slower. I've had good luck in everything I've tried. I shoot just about all the common straight walled cases in revolver and rifle.
I've also used it in a lot of bottle neck cartridges, particularly .30 cal. I like it in the .30-30 with 170gr cast bullets. It also did well in the .308/.30-06/.300 Savage/.300WSM. But usually I pick those when I'm hunting and just go back to my usual higher velocity powders.
You have to love handloading. It brings a whole new dimension to the shooting art.