Not too sure if it will work but think it will...Taurus has the "Judge" pistol and rifle, andthey fire both. Not sure what the bore of those guns are but figure a rifle that will hande the pressures that a "Handi-rifle" will should handle the .410 with ease. The ony other issue to consider would be the extra length of the chamber before the 45LC bullet gets to the lands and grooves. How much leading will occur and if "Ruger only" amo would work ok. Also how much accuracy will suffer if any.