All I hunt is deer. I have both the 308MX and the 338MX; I'm 3 for 3 with the 308MX and 7 for 7 with the 338MX. All were one shot kills and all were DRT with one exception (a short runner), so both with kill deer; but the 308MX, in spite of the fact that I lusted after that thing for a long time before I could actually buy it, has not been out of the gun safe since I brought the 338MX home. For my money, if I could own only one Marlin lever I'd sell everyone I own with the exception of the 338MX, and I have some nice Marlins. That 338 Marlin is one heck of a lever gun/cartridge combination; and you instantly know that the first time you fire the gun! And beside, the fat little 338ME cartridge case is also much cuter than the 308ME case too!