It seems that the 45 carries a lot of baggage with it. History suggests it's abilities are limited and even what should be respected sources perpetuate bad information. John Linebaugh has been playing with this cartridge for years and I trust his opinions and experience. Following his advice and recipes I believe is perfectly safe. I've loaded 45's wild and mild. Old age and old body parts now prefer mild loads. Still, to say that the brass is weak doesn't make sense to me. I get umpteen loadings with Remington, Winchester or Starline brass. Weak brass tends to suggest that the brass contains the rounds pressure. If that were the case, why a steel chamber? I believe the brass only serves to contain the components and then swell and seal the actual chamber. Can a 45 be over loaded? Yes! Can it safely run up to 44 mag pressures. No, not in most guns including the Rugers and Marlins. It doesn't need to though. Equal velocities with equal weight bullets can be had. The larger diameter 45 bullet has less bearing surface than a 44 bullet of the same weight. That allows the 45 bullet to run to equal or even higher velocities with less pressure. That's the beauty of a larger diameter bullet. Saying all this to say, 45 Colts are misunderstood...Like Forrest Gump might say, "That's all I got to say about that."