Ruger level loads will work great with the proper bullet. I have gone past the Ruger level for some loads to run in my 454's with out getting loose primers. Those loads were NOT running 454 pressures but were over 30,000 psi. 454 chambers are cut tighter and support the brass better, case life is fine.
Having said that, I have gotten to know John Linebaugh pretty well in the last 5 years, he is trying to convince me that loads over 1,100- 1,200 fps just aren't needed with good cast bullets. After one penetrates chest to ham and out, how much more do you want? MUCH nicer to shoot as well as giving better penetration, think about sticking you hand out the car window. 30 mph isn't too bad, 60 hits it much harder and 90 you just get your arm hurt. Same thing shooting thru milk jugs of water, more penetration to a point, then penetration starts to decrease. I'm a slow student, but John is persuasive. DP