My first turkey was taken with a Colt Official Police, 38 special, 140 gr. Hornady at about 950 fps. Worked well then, has worked well for the 30 years since. Also successful were 41 mag, 32 S&W Long with a 100 gr. SWC at 1000 fps, 380 ACP with factory Hornady flexitip ammo (22 yards bang/flop), 38 special out of a Detective Special second model, and a Cobra first model, 45 ACP in the old Gold Cup, and probably another 10 I don't remember. All my turkey handgun hunting has been done with regular carrying guns, although I've several Contenders used for deer, antelope, and coyote, it just doesn't seem right to use a scope on Turkey. Personal thing I'm sure.
Go for it. If you're a competent handgunner it makes for a great hunt.