My No. 1 is chambered for the 300 WinMag. I particularly liked the 300 in 125 grain Sierra for antelope on the plains of Colorado and 165 -180 grain Sierra's for deer and larger in the mountains. But that was when I was much younger and fit. Now the rifle makes it out annually or so to still put that firm "kick" to my shoulder. If there is a better hunting rifle than a Ruger No. 1 I have not need to know.