While hunting in Pennsylvania, I've killed a number of deer with a .270. I am a "behind the shoulder" shooter, so I've never felt I've lost a lot of usable meat even with my .270. When hunting Ohio, I used to use a .50 inline muzzleloader, but since the legality of straight-walled rilfe cartridges for deer, I've been using a .45/70. I see no real difference between my ML and my .45/70, even though I load the latter hot (either a 405-grain cast with gas check or a Speer 400-grain JSP) both with a MV of 1,800 fps. I realize that, whether the .270, the ML, or my .45/70, they're all more than is needed to anchor a whitetail. But, they're what I have, I shoot them well, and I'm so darned big and bulky that recoil is not an issue.