Yeah, there's a lot of us "Bob" fans around here.
Like .35Rem stated, the 'Bob is better with the slower burning powders. I started my 'bob loading in 1983 and with some original lot#'s of H4831. With newer lot#'s, I'm seeing over 3,000fps and near 3,100fps with a modest loading at 48.5gr. You can go heavier, but I've seen fabulous accuracy at this loading. On a lark, with a rifle I was having accuracy issues with (Ruger M77MkII), I tried an oldy but goody load of 38.0gr of IMR3031. This got 3,050fps from the Ruger and was the single most accurate load from it and only one to give MOA for 5-shots.
FWIW use bullet without a cannulure. I've gotten best accuracy from Sierra and Speer bullets due to lack of cannulure. Nosler's are good but are un-neccessary for most 'Bob applications. The Hornady "Interloks" are good but often aren't as accurate. The "on-game" performace of the Hornady's has been as good as the Noslers in my experience. Hence, I typically load up on the "blems" that are offered. My current "stash" of .257" bullets are heavy in 100 and 117gr Hornady's. I don't expect sub-moa from the bullets, (though sometimes I pleasantly suprised) but on-game performance leaves nothing wanting.
My favorite load with 115gr loads is 45.0gr of IMR4831. I stumbled across this load working up a load in the above mentioned Ruger for the Berger 115gr VLD. This load gets at or near 3,000fps from the 115gr bullets. With a 117gr Flat-base bullet and all 120's, I drop this to 44.0gr. This is a "sleeper" powder in the 'Bob. Not a lot of print given it, but it has pleased me with every use. Reloader22 hasn't been as good in my experience. Perhaps a tad "slow". H4350 is fast, but in my experience not as accurate as the IMR4350, which is my favorite with 100gr bullets. (45.0gr of course! Gives 2,970fps from my 22" bbl's).
I've found the extruded powders to be more accurate, with IMR4350 a favorite, but don't discount H414 or H380. My Custom M98 Mauser has an E.R.Shaw barrel on it that when new shot these really well. It still does, but has some pitting in the mid-bore area and quickly fouls now. But, with a clean barrel and loads it likes is still sub-moa. For shooting under 300yds, use a flat-base bullet for superior accuracy.
I haven't had time to try it yet in the 'Bob, but from what I'm seeing in the 7mm08 and .30/06; Reloader17 may be the next great thing in the 'Bob....
Due to aquiring a .22-250 in '06, I now no longer expect to shoot bullets lighter than 100gr from the 'Bob. That, and a Remington Mod-7 in .260Rem is my latest "darling" and will be for some time to come.