I have both. The 06 only gets out of the safe for elk or black bear for which I prefer a heavier tougher bullet. The .270 is the same class cartridge but picks up velocity with lighter bullets and works fine on coyotes at a little longer range. For deer and coyotes the .270 is about as good as it gets. If you should get a chance to hunt elk the .270 with a Nosler 150grain or 165 grain still gets the job done properly.