Just got done with a coyote derby :-) I have somewhere north of 2,000 rounds through both calibers. People who choose heavy 243bullets confuse me, they shoot 50-bish grain 22 cal, but 75+ in the 243?!
Most of my 22-250 dogs fell to 40-50gr bullets. IME you won't get anywhere near book speeds, so if you are a numbers junky.... The 22-250 is very easy to load for, and doesn't take allot of fiddling. however you will have random bullet failures, and be a little more selective in shot placement, or follow up with an encore shot.
The 243 has done most of its killing with 55-65gr bullets.
You will get anticipated velocities with the 243, at the cost of a few paltry grains more powder. Meaning relativity speaking, the 250 will burn out throats faster. The 243 won't require follow up shots, and doesn't care where you place the shot. That said, the 243 is world famous for having random pressure excursions. Which is annoying, I already know how to swear, and blowing primers isn't helpful to any cause.
For the potential to let my kids go deer hunting, I choose 243.
I'm a firm believer in the theory that "If it bleeds, I can kill it"
Just do like I did, I have both 243 for woods and long walks and the 22-250 on kickstands for the open reclaimed strip jobs and very short walks. Love both but if I had to pick one it would probably be the 2? Both have their place.
Sorry, forgot to mention I smoked a yote last year at 721 (ranged several times) with the 22" 243 and 58gr. vmax(probably can't do that again) and just this morning head shot a yote between the eyes at 10 yds. (not ranged) with the 26" 22-250 and 40gr. vmax. Now go figure.
I have had both (not in a x series) and liked both there where strictly varmint rigs both done there job when I did mine. The 243 did better in the wind and was cheaper to shoot but the .250 was a blast to use.
But one thing I have seen in the recent ammo buying craze just about everyone has had 22.250