Are you requiring a cast/lead bullet or will jacketed be OK?
I replied to some other .45colt strings, and I'm still fairly early in my load development, but I'm starting to see some consistent "constants" in loading for this cartridge.
First of all, with my 255gr cast bullets, 8.2-8.5gr of Unique for 1,100fps is the most accurate cast bullet load I've found, followed by 18.5gr of Alliant-2400 under a 200gr FN for 1,250fps.
With the plated and jacketed 240-250gr bullets, 1,500 to near 1,600fps is possible with good accuracy. Again, 2400 is what I've used with good results, but my objective has been flat shooting hunting loads for deer/pigs for a point blank range of 125-150yds. Some Rainier 240gr PHP gave me 1,550fps and 3" groups at 50yds. About like the velocity I get from a .50cal muzzleloader w/sabots and 90gr of Pyrodex. Definitely enough for deer/pigs as far as they can be adequately hit.
If not shooting "cowboy" games, I would look hard at the 250gr jacketed bullets for a flatter trajectory and shorter flight time.
Either way, a vernier sight of some sort is a MUST, given the high arch of even the faster jacketed bullets. My Win M94 with factory "open sights", just barely has enough elevation for a 100yd zero with the 250gr bullets ata standard velocities. Though, with the faster jacketed or plated bullets is adequate for up to 150yd zero's.
I'm looking for a suitable vernier open sight (folding, with a "short-range" blade when in folded down position).
I'm not real keen on the tang sights as they compromise the handling of the gun while walking/hunting. I expect to carry the gun FAR MORE in the woods, than shooting it.
For your purposes though, the Vernier Tang sight will be THE way to go.
Good luck with your shooting/load development.