Even with Barnes noted weight retention, either would be too light for my liking. If I had absolutely no other choice, the 300 would get the nod, but nothing other than a broadside shot. I just don't know that there would be enough momentum for deep penetration, should the senario arise of going through a shoulder knuckle if needed. Otherwise, my preference is nothing less than 400 grs. The lightweights may have more speed and energy to start with, but they also shed both faster. Give me penetration, I can live with less energy and range (more trajectory).